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David Sheridan

Department of Biology and Earth Science

Assistant Professor

B.A., University of Minnesota, 1994
M.S., University of Wisconsin, 2000
Ph.D., University of Wisconsin, 2003

Research and Teaching Interests

Dave teaches courses in anatomy & physiology and vertebrate systems physiology. He is a cellular physiologist with particular interests in neurons and skeletal muscle cells. His research focuses on 1) how cortical and olfactory bulb neurons respond to different patterns of stimulation and 2) how and which ion channels are involved in the excitability of different cells. He employs techniques from electrophysiology, molecular biology, and pharmacology to try to answer these questions. At Otterbein, he has expanded his research foci to include how different chemical messengers, like stress hormones, can affect the inputs and outputs of excitable cells.


  • Sheridan DC, Carbonneau L, Ahern CA, Nataraj P, and Coronado R (2003) Ca2+-dependent excitation-contraction coupling triggered by the heterologous cardiac/brain DHPR β2a subunit in skeletal muscle. Biophys. J. 85 (6): 3739-3757.
  • Sheridan DC, Cheng W, Carbonneau L, Ahern CA, Coronado R (2004) Involvement of a heptad repeat in the carboxyl terminus of the dihydropyridine receptor β1a subunit in the mechanism of excitation-contraction coupling. Biophys. J. 87 (2): 929-942.
  • Coronado R, Ahern CA, Sheridan DC, Cheng W, Carbonneau L, Bhattacharya D (2004) Functional equivalence of dihydropyridine receptor α1S and β1a subunits in triggering excitation-contraction coupling in skeletal muscle. Biol. Res. 37 (4): 565-575.
  • Carbonneau L, Bhattacharya D, Cheng W, Sheridan DC, Coronado R (2005) Multiple loops of the dihydropyridine receptor pore subunit are required for full-scale excitation-contraction coupling in skeletal muscle. Biophys. J. 89 (1): 243-255.
  • Sheridan DC, Takekura H, Franzini-Armstrong C, Beam KG, Allen PD, Perez CF (2006) Bi-directional signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions. Proc. Natl. Acad. Sci. USA. 103 (52): 19760-19765.
  • Sheridan DC, Moua O, Lorenzon NM, Beam KG (2012) Bimolecular fluorescence complementation and targeted biotinylation provide insight into the topology of the skeletal muscle Ca2+ channel β1a subunit. Channels (Austin). 6 (1): 26-40.
  • Sheridan DC, Hughes AR, Erdelyi F, Szabo G, Hentges ST, Schoppa NE (2014) Matching of feedback inhibition with excitation ensures fidelity of information flow in the anterior piriform cortex. Neuroscience. 275: 519-530.


SCI 221